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  • Title: [Prognosis and treatment of glomerulonephritis of periarteritis nodosa. The role of plasma exchange].
    Author: Jarrousse B, Guillevin L, Gie S, Bletry O, Barrier J, Cassuto-Viguier E, Ang KS, Besancenot JF, Sobel A.
    Journal: Ann Med Interne (Paris); 1988; 139 Suppl 1():23-5. PubMed ID: 2907849.
    Abstract:
    Fourteen patients with polyarteritis nodosa complicated by histologically confirmed glomerulopathies were included in a prospective multi-center study comparing corticotherapy (group 1, n = 8) with combined cyclophosphamide and steroids (group 2, n = 6). Plasma exchanges were associated on a routine basis. The two groups were comparable apart from initially more severe renal impairment in group 1 (p less than 0.05). Initial control of the disease was obtained in 11 patients (7 from group 1, 4 from group 2) including the patients with oligoanuria. Six patients recovered, 3 had recurrence requiring chronic hemodialysis and 5 patients died from group 1 (p less than 0.05). These preliminary findings suggest that plasma exchange can contribute to control of polyarteritis nodosa with renal complications.
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