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  • Title: [Experimental study scavenging effect of paraquat by hemoperfusion].
    Author: Pei YH, He YZ, Zhang XG, Sun BS.
    Journal: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi; 2017 Jul 20; 35(7):523-525. PubMed ID: 29081105.
    Abstract:
    Objective: To determine the scavenging effect and the change of metabolism of paraquat (PQ) using hemoperfusion (HP) once and twice within 12 hours after intoxication and explore the better scheme of HP. Methods: 18 beagles were randomly divided into 3 groups. Single HP group, Double HP group and Control group. Peripheral veins blood was collected at different times within 48 hours after exposure in each group. Toxin concentration was measured, analyzed and compared among 3 groups. Results: 6 hours after exposure, Single HP group and Double HP group has finished the first HP treatment, and the concentration of PQ was lower than that of the control group, the difference was statistically significant (P<0.05) . 10 hours after exposure, there was no statistical difference of toxin concentration among 3 groups (P>0.05) . 12 hours after exposure, Double HP group has finished the second HP treatment, the concentration of PQ was significantly lower than that of Single HP group and Control group (P<0.05) . 24 hours and 48 hours after exposure, there was no statistical difference of toxin concentration among 3 groups (P>0.05) . Statistical difference were not observed in toxicokinetical parameters among 3 groups (P>0.05) . Conclusion: HP treatment once and twice within 12 hours after intoxication could effectively reduce the toxin concentration in the peripheral veins blood after HP for about 4 hours, then the toxin concentration would return to the same level as Control group quickly. It was suggested that at the beginning of poisoning, HP treatment once or twice could not significantly change the metabolism of paraquat. 目的： 探讨百草枯中毒后早期行单次及二次血液灌流（hemoperfusion HP）对染毒犬血液中毒物的清除效果及毒物代谢改变，以探索更优HP方案。 方法： 将18只比格犬随机分为3组：单次HP治疗组、二次HP治疗组及对照组。采集各组比格犬百草枯染毒后48 h内不同时间点的外周静脉血，测量、分析并比较血浆中的毒物浓度。 结果： 染毒后6 h，单次HP组及二次HP组结束首次HP治疗，PQ浓度明显低于对照组，差异有统计学意义（P<0.05）；染毒后10 h，三组PQ浓度的差异无统计学意义（P>0.05）；染毒后12 h，二次HP组结束第二次HP治疗，其PQ浓度明显低于单次HP组及对照组，差异有统计学意义（P<0.05）；染毒后24h及48h，各组PQ浓度差异无统计学意义（P>0.05）。各组在毒代动力学参数比较，差异无统计学意义（P>0.05）。 结论： 中毒后12 h内的单次及二次HP治疗在灌流后短时间内可有效降低血液中的百草枯浓度，但在HP后短时间内恢复至同一水平；提示中毒初期单次或二次HP治疗不能明显改变百草枯的毒物代谢。.
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