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  • Title: Overexpression of Aspergillus nidulans α-1,3-glucan synthase increases cellular adhesion and causes cell wall defects.
    Author: He X, Li S, Kaminskyj SGW.
    Journal: Med Mycol; 2018 Jul 01; 56(5):645-648. PubMed ID: 29087495.
    Abstract:
    Alpha-1,3-glucan is important for pathogenesis by Aspergillus fumigatus, but the mechanism is unclear since the deletion has no hyphal phenotype. We dissected the roles of A. nidulans α-1,3-glucan in constitutive overexpression strains. Constitutive high-level α-1,3-glucan synthase activity increased hyphal wall thickness, but colonies grew slowly and sporulated poorly and had much higher adhesion to hydrophobic materials. Surprisingly, this overexpression strain formed a biofilm-like structure in plastic culture wells that was as adhesive as wild-type A. fumigatus. These results suggest α-1,3-glucan has important roles in fungal cellular adhesion and may contribute to fungal pathogenesis.
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