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  • Title: Somatostatin inhibits the secretion of bombesin-like peptides from small cell lung cancer cells.
    Author: Kee KA, Finan TM, Korman LY, Moody TW.
    Journal: Peptides; 1988; 9 Suppl 1():257-61. PubMed ID: 2908812.
    Abstract:
    The effects of somatostatin (SRIF) on small cell lung cancer (SCLC) cell line NCI-H345 was investigated. SRIF had no effects on the basal cAMP levels or the secretion rate of bombesin-like peptides. VIP (1 microM) increased the cAMP levels approximately 10-fold and the secretion rate of bombesin-like peptides 3-fold. SRIF and its analogues inhibited the increase in the cAMP levels and the secretion rate of bombesin-like peptides caused by VIP. The order of peptide potency was (D-Trp8)SRIF > SRIF-28 = (Tyr11)SRIF > SRIF. These data suggest that functional SRIF receptors may be present on SCLC cells.
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