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  • Title: Some specific neurological complications of acute lymphocyte leukaemia of childhood.
    Author: Appleton DB, Isles AF, Tiernan JR.
    Journal: Clin Exp Neurol; 1978; 15():271-8. PubMed ID: 290981.
    Abstract:
    Aggressive chemotherapy and prophylactic central nervous system irradiation have increased the survival time of children with acute lymphatic leukaemia. As a result of treatment complex neurological problems are appearing. Computerized axial tomography allows more definite elucidation of these problems. 7 of 11 treated patients studied by this technique showed the presence of intracranial calcification and patchy cerebral atrophy, raising the questions of the quality of survival and the relationship of the findings to the cytotoxic drugs used.
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