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  • Title: Integrin-linked kinase: A new actor in the ageing process?
    Author: Olmos G, López-Ongil S, Ruiz Torres MP.
    Journal: Exp Gerontol; 2017 Dec 15; 100():87-90. PubMed ID: 29101014.
    Abstract:
    Integrin-linked kinase (ILK) is a protein located in focal adhesion complexes that is linked to the cytoplasmic domain of integrin receptors. Together with PINCH and parvin, ILK forms the IPP complex, which is associated with conserved intracellular signalling pathways and integrin regulation of the actin cytoskeleton. ILK plays an essential role in a wide variety of cellular functions, including cell migration, differentiation, survival, and division. The present review summarizes recent evidence, suggesting a new role for ILK in organismal ageing and cellular senescence, indicating that ILK is a key regulator of longevity and premature cellular senescence induced by extracellular stressors.
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