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  • Title: Low-Grade Astrocytoma within a Mature Cystic Teratoma in an Adolescent Patient.
    Author: Yoder N, Marks A, Hui P, Litkouhi B, Cron J.
    Journal: J Pediatr Adolesc Gynecol; 2018 Jun; 31(3):325-327. PubMed ID: 29107097.
    Abstract:
    BACKGROUND: Mature cystic teratomas are the most common ovarian neoplasm in adolescents. They are typically benign, however, malignant transformation rarely occurs. We report a low-grade astrocytoma arising from a mature cystic teratoma in an adolescent patient. CASE: The patient was a 12-year-old girl with an asymptomatic ovarian cyst and subsequent cystectomy. Final pathology identified a solid tumor with glial tissue within the cyst, reported as low-grade astrocytoma arising in a mature cystic teratoma. SUMMARY AND CONCLUSION: There are few data on astrocytomas in the gynecologic tract. Risk factors for malignant transformation in a mature cystic teratoma include increased age, postmenopausal status, elevated carcinoma antigen 125, and large tumor size. Interestingly, this patient had a history of partial trisomy 20, which has been associated with teratoma formation in a mouse model.
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