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  • Title: Renovascular hypertension in children. Surgical repair with special reference to the use of reinforced vein grafts.
    Author: Berkowitz HD, O'Neill JA.
    Journal: J Vasc Surg; 1989 Jan; 9(1):46-55. PubMed ID: 2911142.
    Abstract:
    Surgical correction of renovascular hypertension in children is especially challenging because there is high incidence of bilateral renal artery lesions and stenosis of the abdominal aorta. Seventeen patients with severe hypertension, whose ages ranged from 2 to 16 years (mean 10.2 years), had surgical repair of these lesions from 1974 to 1987. Twenty-nine renal artery lesions were repaired. Twelve (71%) were bilateral, five (29%) were unilateral, and eight patients (47%) had abdominal aortic lesions (midaortic stenosis). Twenty-eight saphenous vein grafts and one splenorenal graft were used to bypass the renal artery lesions. The midaortic lesions were bypassed with Dacron grafts from the superceliac aorta to the aortic bifurcation. No operative deaths occurred. Nineteen of the 28 vein grafts were reinforced with a 6 mm diameter tubular Dacron mesh to prevent aneurysmal degeneration seen in three of nine unsupported vein grafts. Follow-up arteriograms were available in 15 patients up to 11 years after operation (mean 5.0 years). There has been no aneurysmal dilatation in the 19 mesh-supported grafts. The ratio of vein graft diameter to the diameter of the native aorta was 1.25 +/- 0.38 (+/- standard deviation) in unsupported grafts and 0.65 +/- 0.09 in mesh-supported grafts, representing a 92% increased diameter in the unsupported grafts. Three vein grafts (10.3%) required percutaneous transluminal angioplasty for late postoperative vein graft stenoses, but no stenotic lesions have developed at the aortic suture lines. One graft occluded 7 years postoperatively after replacement of an aneurysmal vein graft, and one early postoperative graft occlusion occurred, for a graft failure rate of 7%. Seventy-six percent of patients (13 of 17) are normotensive without medication, and 24% (4 of 17) are considered improved with hypertension controlled with a lower dose of medication. Our results attest to the safety and efficacy of this complicated surgery. Saphenous veins, supported by external Dacron mesh, appear to be a suitable graft material for renal reconstruction in this population.
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