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  • Title: The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo.
    Author: Driever W, Nüsslein-Volhard C.
    Journal: Nature; 1989 Jan 12; 337(6203):138-43. PubMed ID: 2911348.
    Abstract:
    A gradient in concentration of the protein product of the bicoid gene is a determinant of the anterior-posterior axis of Drosophila embryos. By binding upstream of the segmentation gene hunchback the bicoid protein controls its transcription, thereby translating maternal pattern-generating information into differential activation of zygotic gene expression.
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