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  • Title: A 12 megabase restriction map at the cystic fibrosis locus.
    Author: Fulton TR, Bowcock AM, Smith DR, Daneshvar L, Green P, Cavalli-Sforza LL, Donis-Keller H.
    Journal: Nucleic Acids Res; 1989 Jan 11; 17(1):271-84. PubMed ID: 2911467.
    Abstract:
    We have constructed a physical map of the chromosomal region containing the cystic fibrosis locus using seven DNA markers and pulsed-field gel electrophoresis methods. The map includes cleavage sites for 8 rare-cutting restriction enzymes and spans over 12 megabases (Mb) of DNA, with one unlinked probe covering an additional 5 Mb. To our knowledge, this is the largest segment of human DNA which has been restriction-mapped to date. We can identify thirteen putative HTF islands spaced at intervals of 0.3-3.2 Mb. The region between loci D7S8 and MET, where the CF gene lies, includes 1.4-1.9 Mb of DNA.
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