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  • Title: Photoinduced Remote Functionalisations by Iminyl Radical Promoted C-C and C-H Bond Cleavage Cascades.
    Author: Dauncey EM, Morcillo SP, Douglas JJ, Sheikh NS, Leonori D.
    Journal: Angew Chem Int Ed Engl; 2018 Jan 15; 57(3):744-748. PubMed ID: 29114978.
    Abstract:
    A photoinduced cascade strategy leading to a variety of differentially functionalised nitriles and ketones has been developed. These reactions rely on the oxidative generation of iminyl radicals from simple oximes. Radical transposition by C(sp3 )-(sp3 ) and C(sp3 )-H bond cleavage gives access to distal carbon radicals that undergo SH 2 functionalisations. These mild, visible-light-mediated procedures can be used for remote fluorination, chlorination, and azidation, and were applied to the modification of bioactive and structurally complex molecules.
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