These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Gene polymorphisms of Interleukin 1? and Metalloproteinase 3 in Hepatitis C Infected Patients and Hepatocellular Carcinoma Patients.
    Author: ElSheshtawy NM, Nour MS, Hefny Z, Samir A.
    Journal: Egypt J Immunol; 2017 Jan; 24(1):1-8. PubMed ID: 29120572.
    Abstract:
    Cytokines as IL 1? and matrix metalloproteinases (MMPs) are involved in tumor growth, invasion, and remote metastasis in various cancers. IL-1? ?31T/C polymorphism in the promoter region has been linked to an elevated risk of Hepatocellular carcinoma (HCC). MMP3 polymorphism at 1171 has also been linked to an elevated risk and a highly invasive type of HCC. Studying the association between IL-1? 31C/T gene polymorphism and MMP3 11715A/6A gene polymorphism in cases of Hepatitis C virus (HCV) and HCC. The study was done on 20 HCV infected patients, 20 HCC patients and 15 healthy controls. IL-1? 31 C/T and MMP3 1171 5A/6A gene polymorphisms was investigated using restriction fragment length polymorphism discrimination assay. Data revealed that the frequency of IL-1? C/T and MMP3 5A/6A polymorphisms was higher in patient groups (HCC and HCV) compared with healthy controls. A significant association was found between IL-1? C/T, MMP3 5A/6A polymorphism and HCC susceptibility. In conclusion, IL-1? C/T and MMP3 5A/6A polymorphisms are associated with an increased risk of developing HCC in Egyptian patients.
    [Abstract] [Full Text] [Related] [New Search]