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  • Title: Triiodothyronine, thyroxine, and TSH response to dexamethasone in depressed patients and normal controls.
    Author: Rupprecht R, Rupprecht C, Rupprecht M, Noder M, Mahlstedt J.
    Journal: Biol Psychiatry; 1989 Jan; 25(1):22-32. PubMed ID: 2912508.
    Abstract:
    In view of recent investigations concerning alterations of thyroid function in depression, the pre- and postdexamethasone levels of T3, T4, and TSH of 14 patients during depression and after recovery were studied, in addition to those of 27 healthy controls. A reduction of T3 and TSH levels was shown to be dependent on the depressive state, with a tendency to lower T4 levels after recovery. Dexamethasone had a pronounced suppressive effect on TSH levels in healthy controls and in patients after recovery, but not during the depressive episode. These results point to an inadequate suppressibility of the hypothalamo-pituitary-thyroid (HPT) axis to dexamethasone during depression. There are close interrelations between the hypothalamo-pituitary-adrenal (HPA) and the HPT axes that are possibly affected during depressive illness.
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