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  • Title: Jaundice and intrahepatic cholestasis following high-dose megestrol acetate for breast cancer.
    Author: Foitl DR, Hyman G, Lefkowitch JH.
    Journal: Cancer; 1989 Feb 01; 63(3):438-9. PubMed ID: 2912522.
    Abstract:
    High-dose megestrol acetate, a synthetic progestin, has been advocated recently in treating patients with metastatic breast carcinoma; no significant increase in adverse effects has been reported. This report describes a patient with jaundice and intrahepatic cholestasis after high-dose megestrol acetate therapy. This cholestatic lesion may have a pathogenesis similar to that observed with estrogens and oral contraceptives.
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