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  • Title: Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates.
    Author: Faidallah HM, Girgis AS, Tiwari AD, Honkanadavar HH, Thomas SJ, Samir A, Kalmouch A, Alamry KA, Khan KA, Ibrahim TS, Al-Mahmoudy AMM, Asiri AM, Panda SS.
    Journal: Eur J Med Chem; 2018 Jan 01; 143():1524-1534. PubMed ID: 29126731.
    Abstract:
    A set of 1,2,3-triazole incorporated quinolone antibiotic conjugates 10-15, 17-19 were synthesized via microwave assisted click chemistry technique. Some of the aryl-substituted conjugates 17-19 show promising antibacterial properties against the tested Gram-positive (S. aureus and S. pyogenes) and Gram-negative bacteria (S. typhi) with potency higher than that of the parent antibiotics 1-3. 2D-QSAR modeling supports the observed biological properties.
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