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  • Title: Characterization with monoclonal and polyclonal antibodies of a new major allergen from grass pollen in the group I molecular weight range.
    Author: van Ree R, Clemens JG, Aalbers M, Stapel SO, Aalberse RC.
    Journal: J Allergy Clin Immunol; 1989 Jan; 83(1):144-51. PubMed ID: 2913133.
    Abstract:
    We have purified a 24/25 kd allergen from orchard grass pollen (Dactylis glomerata) that has an allergenic potency similar to that of the major group I allergen. We provisionally named this allergen grass 4B1 after the monoclonal antibody used for its identification and purification. This monoclonal antibody was obtained by immunizing mice with whole Lolium perenne-pollen extract and by screening the antibody producing hybrids for reactivity with Dactylis glomerata-pollen extract. Grass 4B1 is physicochemically separable from the group I allergen. Polyclonal rabbit antibodies to grass 4B1 do not react with group I allergen or vice versa. Ninety-five sera with IgE antibodies to grass pollen were tested for IgE antibodies to grass 4B1, and greater than 90% was positive in this test. The median response to grass 4B1 was 70% of that to Lol p I.
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