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  • Title: Molecular epidemiology of β-lactamase production in penicillin-susceptible Staphylococcus aureus under high-susceptibility conditions.
    Author: Matono T, Nagashima M, Mezaki K, Motohashi A, Kutsuna S, Hayakawa K, Ohmagari N, Kaku M.
    Journal: J Infect Chemother; 2018 Feb; 24(2):153-155. PubMed ID: 29132926.
    Abstract:
    Little is known about the prevalence of β-lactamase production in penicillin-susceptible Staphylococcus aureus isolates under high-susceptibility conditions. We analyzed S. aureus isolates with penicillin G minimum inhibitory concentration (MIC) ≤ 0.12 μg/ml that were recovered from in-/outpatients (n = 108) between 2016 and 2017 in Japan. β-Lactamase production was detected by nitrocefin-based and Clinical and Laboratory Standards Institute penicillin zone edge testing and blaZ PCR. All isolates were categorized as having penicillin G MIC ≤0.03 μg/ml using an automated system; MICs determined based on the microdilution method were 0.016 μg/ml (2%), 0.03 μg/ml (44%), and 0.06 μg/ml (54%). Notably, no isolates harbored the blaZ gene. The results from the nitrocefin-based and zone edge tests were consistent with those obtained by PCR. S. aureus isolates with penicillin G MIC ≤0.03 μg/ml exhibited a low frequency of β-lactamase production. Thus, screening for β-lactamase production may be unnecessary for isolates showing such high susceptibility.
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