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  • Title: Quantitative analysis of senecavirus A in tissue samples from naturally infected newborn piglets.
    Author: Dall Agnol AM, Miyabe FM, Leme RA, Oliveira TES, Headley SA, Alfieri AA, Alfieri AF.
    Journal: Arch Virol; 2018 Feb; 163(2):527-531. PubMed ID: 29134335.
    Abstract:
    In this study, we determined the distribution of senecavirus A (SVA) and viral RNA load in different organs and tissues of naturally infected piglets. A TaqMan-based qRT-PCR assay was performed using RNA extracted from brainstem, cerebellum, cerebrum, heart, kidney, liver, lungs, small intestine, spleen, urinary bladder, and tonsils of seven newborn piglets. SVA was detected in 57 out of 70 tissue samples (81.4%). Viral loads ranged from 4.07 to 10.38 log10 genomic copies per g of tissue. The results show that SVA has tropism for various organs in naturally infected newborn piglets, especially for tonsils, spleen, lungs, and liver. Lymphoid organs had the highest viral loads and may be important sites for SVA replication.
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