These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: 18F-FDG-PET/CT versus 99Tcm-MIBI-SPECT: which is better for detection of solitary pulmonary nodules ?
    Author: Xia G, An C, Ming Z, Guo H, Liu L, Li Y.
    Journal: J BUON; 2017; 22(5):1246-1251. PubMed ID: 29135109.
    Abstract:
    PURPOSE: To compare the diagnostic value of 99Tcm-MIBI- SPECT and 18F-FDG-PET/CT in differentiating benign from malignant solitary pulmonary nodules (SPNs). METHODS: 170 SPNs were involved in this study (78 with 99Tcm-MIBI-SPECT and 92 with 18F-FDG-PET/CT). Definite diagnosis of SPNs was determined by biopsy. The diagnostic efficiency of 99Tcm-MIBI-SPECT and 18F-FDGPET/ CT in differentiating benign from malignant SPNs was analyzed and compared. RESULTS: Seventy-eight patients with SPNs were examined with 99Tcm-MIBI-SPECT (26 with malignant SPNs and 52 with benign SPNs). The sensitivity, specificity and accuracy of 99Tcm-MIBI-SPECT were 92.31, 88.46 and 89.74%, respectively. The positive predictive value (PPV) and negative predictive value (NPV) were 80 and 95.83%, respectively. Ninety-two individuals with SPNs were examined using 18F-FDG-PET/CT (58 with malignant SPNs and 34 with benign SPNs). The sensitivity, specificity and accuracy of 18F-FDG-PET/CT were 96.55, 76.47 and 89.13%, respectively. The PPV and NPV were 87.50 and 92.86%, respectively. Statistical significance was not detected in sensitivity, specificity, accuracy, PPV and NPV between these two methods. CONCLUSION: 99Tcm-MIBI-SPECT has comparable diagnostic value with 18F-FDG-PET/CT in differentiating benign from malignant SPNs. Considering its easy availability and low-cost, 99Tcm-MIBI-SPECT could be an alternative imaging modality in differentiating benign from malignant SPNs in areas with a backward economy.
    [Abstract] [Full Text] [Related] [New Search]