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  • Title: Adrenal insufficiency in critical patients: New ethiopathogenic concepts and therapeutic implications.
    Author: Mateos Moreno L, Palacios García N, Estrada García FJ.
    Journal: Endocrinol Diabetes Nutr; 2017 Dec; 64(10):557-563. PubMed ID: 29137961.
    Abstract:
    Recently, there have been advances in understanding of the changes that occur in the hypothalamic-pituitary-adrenal axis during the different stages of critical disease. Such advances have led to a paradigm change, so that the aforementioned adaptations are no longer considered the result of adrenal axis activation, but a consequence of decreased cortisol metabolism illness. Knowledge of this new pathophysiological bases should lead to reconsider the diagnosis and treatment of adrenal insufficiency in critically ill patients, a condition poorly understood to date.
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