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  • Title: Relationship between alveolar saturated phosphatidylcholine pool sizes and compliance of preterm rabbit lungs. The effect of maternal corticosteroid treatment.
    Author: Ikegami M, Jobe AH, Yamada T, Seidner S.
    Journal: Am Rev Respir Dis; 1989 Feb; 139(2):367-9. PubMed ID: 2913885.
    Abstract:
    The relationship between alveolar saturated phosphatidylcholine pool size and compliance was evaluated in control and maternal corticosteroid-treated 27-, 28-, and 29-day gestational age preterm ventilated rabbits. Surfactant pool sizes below about 0.7 mumol saturated phosphatidylcholine/kg body weight did not alter compliance in either group. Compliance increased to values comparable to surfactant-treated or term newborn rabbits over a narrow range of saturated phosphatidylcholine pool sizes from about 0.7 to 1.2 mumol/kg for corticosteroid-treated rabbits and from about 0.9 to about 2.3 mumol/kg for control rabbits (p less than 0.01). When these results are compared with those from surfactant-treated rabbits, almost an order of magnitude less endogenous surfactant than exogenous surfactant is needed to alter compliance in preterm ventilated rabbits.
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