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  • Title: Eudesmane and aromadendrane sesquiterpenoids from the Vietnamese soft coral Sinularia erecta.
    Author: Huong NT, Ngoc NT, Thanh NV, Dang NH, Cuong NX, Nam NH, Thung DC, The HV, Tuan VS, Kiem PV, Minh CV.
    Journal: Nat Prod Res; 2018 Aug; 32(15):1798-1802. PubMed ID: 29144177.
    Abstract:
    Using various chromatographic separations, eight sesquiterpenoids (1-8), including one new compound 3β,5α-dihydroxyeudesma-4(15),11-diene (1), were isolated from the MeOH extract of the Vietnamese soft coral Sinularia erecta. The structure elucidation was confirmed by spectroscopic experiments including 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities against three human cancer cell lines (A-549, HeLa and PANC-1) of all isolated compounds were evaluated by MTT-based colorimetric assays. Compound 1 exhibited selective cytotoxicity against the A549 cell line with IC50 of 14.79 ± 0.91 μM.
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