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  • Title: Isolation and molecular characterization of a urease-negative Actinobacillus pleuropneumoniae mutant.
    Author: Ito H, Takahashi S, Asai T, Tamura Y, Yamamoto K.
    Journal: J Vet Diagn Invest; 2018 Jan; 30(1):172-174. PubMed ID: 29145759.
    Abstract:
    An atypical urease-negative mutant of Actinobacillus pleuropneumoniae serovar 2 was isolated in Japan. Nucleotide sequence analysis of the urease gene cluster revealed that the insertion of a short DNA sequence into the cbiM gene was responsible for the urease-negative activity of the mutant. Veterinary diagnostic laboratories should be watchful for the presence of aberrant urease-negative A. pleuropneumoniae isolates.
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