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  • Title: An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence.
    Author: Walczak A, Przybyłowska-Sygut K, Sygut A, Cieślak A, Mik M, Dziki Ł, Dziki A, Majsterek I.
    Journal: Pol Przegl Chir; 2017 Oct 31; 89(5):1-5. PubMed ID: 29154245.
    Abstract:
    THE AIM OF THE STUDY: We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. MATERIAL AND METHODS: Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism. CONCLUSION: The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.
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