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  • Title: [ZNS complications in children with acute lymphatic leukemia. Computer tomographic studies].
    Author: Meyer E, Ludwig R.
    Journal: Fortschr Med; 1979 Sep 13; 97(34):1471-5. PubMed ID: 291567.
    Abstract:
    78 children with acute lymphoblastic leukemia or non-Hodgkin-lymphoma were treated at the Children's Hospital of the University of Heidelberg from December 1971 to April 1979. Following cytostatic treatment and irradiation of the skull 11 children developed CNS-symptoms (mainly seizures and paresis) which were caused by intracerebral hemorrhage, infectious or degenerative CNS-diseases. Cranial axial tomography (CAT) was helpful in finding the cause of the CNS-complication. We recommend routine CAT in the beginning and during the course of treatment of leukemia to document CNS-changes as early as possible and to prevent further damage by alterations of therapy.
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