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  • Title: The Role of Interleukin-6 in Castleman Disease.
    Author: Yoshizaki K, Murayama S, Ito H, Koga T.
    Journal: Hematol Oncol Clin North Am; 2018 Feb; 32(1):23-36. PubMed ID: 29157617.
    Abstract:
    Since its discovery, improvements in treating Castleman disease and its variants have centered on interleukin-6 (IL-6). IL-6 was discovered from T-cell factors (BCDF or BSF-2), which induced B-cell maturation. Most symptoms of the plasma cell variant of Castleman disease are linked to the hyperfunction of IL-6, constitutively produced in the affected lymph nodes (1989), suggesting IL-6 is key in the pathogenesis of multicentric Castleman disease (MCD). The results of several studies have shown that most MCD symptoms and abnormal laboratory results are improved by anti-IL-6 MCD treatments, such as tocilizumab, a humanized anti-IL-6 receptor antibody, and siltuximab, an anti-IL-6 antibody.
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