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  • Title: Simultaneous existence of double minute chromosomes and a homogeneously staining region in a retinoblastoma cell line (Y79) and amplification of N-myc at HSR.
    Author: Inazawa J, Abe T, Inoue K, Nishigaki H, Horiike S, Taniwaki M, Misawa S, Takino T.
    Journal: Cancer Genet Cytogenet; 1989 Jan; 37(1):133-7. PubMed ID: 2917328.
    Abstract:
    We observed double minute chromosomes (dmin) and a homogeneously staining region (HSR) in the same metaphase cells obtained from a retinoblastoma cell line, Y79. All of the 132 metaphases examined contained an HSR on the short arm of chromosome 1(1pHSR) and five cells (3.8%) had two to four dmin. To determine whether 1pHSR and dmin carried amplified N-myc sequences, we performed an in situ hybridization using an N-myc probe. Silver grains clustered on and along the 1pHSR, but not on the dmin. These findings indicate that the HSR on chromosome 1 is associated with amplification of N-myc in Y79 cells.
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