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  • Title: Endothelial Shear Stress of the Saphenous Vein Composite Graft Based on the Internal Thoracic Artery.
    Author: Hwang HY, Koo BK, Yeom SY, Kim TK, Kim KB.
    Journal: Ann Thorac Surg; 2018 Feb; 105(2):564-571. PubMed ID: 29174786.
    Abstract:
    BACKGROUND: Endothelial shear stress (ESS) has been suggested as a factor affecting atherosclerosis and remodeling of native vessels and bypass conduits. We compared ESS levels of internal thoracic artery (ITA) and saphenous vein (SV) composite grafts intraoperatively and 1 year after coronary artery bypass grafting (CABG). METHODS: Intraoperative ESS was calculated by measuring flow volumes and diameters of proximal and distal ITAs and SV conduits in 23 patients who received SV Y-composite grafts based on the in situ left ITA. Early (1.2 ± 0.5 days) and 1-year (12.9 ± 1.1 months) postoperative angiograms were performed in 23 and 15 patients, respectively. An intragraft Doppler-guidewire study for ESS measurement was performed in 6 patients during 1-year angiography. RESULTS: Intraoperative diameters of proximal and distal ITAs and SV conduits were 2.0 ± 0.2 mm, 1.8 ± 0.3 mm, and 3.2 ± 0.4 mm, respectively. ESS levels were significantly different between them (41.0 ± 21.0, 28.4 ± 25.2, and 4.3 ± 3.0 dyne/cm2, respectively). Proximal and distal ITA diameters increased significantly on early angiograms and remained unchanged, but SV diameter increased to 3.7 mm (95% confidence interval, 3.5 to 4.0 mm; p < 0.001) on the early angiogram and decreased to 2.9 mm (95% confidence interval, 2.7 to 3.2 mm; p < 0.001) at 1 year. Significant correlations were found between the initial ESS and proportional changes in conduit diameters during postoperative year 1. SV ESS increased in all 6 patients at 1 year, with no significant differences in ESS levels between the 3 conduits (29.9 ± 7.9, 28.8 ± 7.9, and 21.6 ± 16.3 dyne/cm2, respectively). CONCLUSIONS: Initial ESS appears to be associated with proportional changes in conduit diameters in the first year after CABG. ESS values of SV composite grafts were similar to left ITA conduits 1 year after CABG.
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