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  • Title: Growth hormone stimulates insulin-like growth factor I actions on adult articular chondrocytes.
    Author: Smith RL, Palathumpat MV, Ku CW, Hintz RL.
    Journal: J Orthop Res; 1989; 7(2):198-207. PubMed ID: 2918420.
    Abstract:
    We report effects of adding insulin-like growth factor I (IGF-I) and methionyl human growth hormone (GH), alone or in combination, to adult bovine articular chondrocytes plated at high density. Purified human and synthetic IGF-I stimulated chondrocyte DNA and proteoglycan synthesis. GH had no effect on either process. However, GH added in combination with IGF-I increased proteoglycan, cell-associated proteoglycan, and keratan sulfate synthesis over levels observed with IGF-I alone. IGF-I and GH did not alter the hydrodynamic size of proteoglycans or synthesis of collagen. Our results show that GH and IGF-I act together to stimulate adult chondrocyte extracellular matrix synthesis.
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