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  • Title: [Metformin-associated lactic acidosis. Report of one case].
    Author: Quintana F, Pezzani MJ, Orozco R, Dreyse J, Soto L, Regueira T.
    Journal: Rev Med Chil; 2017 Aug; 145(8):1072-1075. PubMed ID: 29189867.
    Abstract:
    Metformin-associated lactic acidosis is a severe and infrequent adverse event. Early diagnosis is essential to start an early treatment, which often has favorable results. We report a 56 years old non-insulin-requiring type 2 diabetic female who developed a severe metabolic acidosis associated with metformin in relation to an acute renal failure secondary to infectious diarrhea. Early treatment with bicarbonate and continuous hemofiltration allowed a quick improvement of the patient. Metformin-associated lactic acidosis has an elevated mortality (50-80%) and has a specific and effective treatment. Therefore, the condition must be born in mind.
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