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  • Title: Carbonylative Coupling of Alkyl Zinc Reagents with Benzyl Bromides Catalyzed by a Nickel/NN2  Pincer Ligand Complex.
    Author: Andersen TL, Donslund AS, Neumann KT, Skrydstrup T.
    Journal: Angew Chem Int Ed Engl; 2018 Jan 15; 57(3):800-804. PubMed ID: 29193522.
    Abstract:
    An efficient catalytic protocol for the three-component assembly of benzyl bromides, carbon monoxide, and alkyl zinc reagents to give benzyl alkyl ketones is described, and represents the first nickel-catalyzed carbonylative coupling of two sp3 -carbon fragments. The method, which relies on the application of nickel complexed with an NN2 -type pincer ligand and a controlled release of CO gas from a solid precursor, works well with a range of benzylic bromides. Mechanistic studies suggest the intermediacy of carbon-centered radicals.
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