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  • Title: Effectiveness of the repeated administration of scopolamine ointment on clozapine-induced hypersalivation in patients with treatment-resistant schizophrenia: A preliminary study.
    Author: Takeuchi I, Hanya M, Uno J, Fujita K, Kamei H.
    Journal: Asia Pac Psychiatry; 2017 Dec; 9(4):. PubMed ID: 29193710.
    Abstract:
    INTRODUCTION: This study investigated the efficacy of scopolamine (an anticholinergic agent) ointment against clozapine-induced hypersalivation. METHODS: The patients enrolled in this study consisted of 10 clozapine-treated schizophrenia patients and 10 healthy adult men. A prospective, randomized, double-blind, crossover, placebo-controlled clinical trial was designed. RESULTS: A total of 10 patients and 10 healthy adult men completed the study. No significant reduction in the saliva production of the clozapine-treated patients was observed; however, that of the healthy adult men decreased significantly. DISCUSSION: Scopolamine ointment was not effective against clozapine-induced hypersalivation. A further study is necessary for confirming its effect.
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