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  • Title: Dihydroartemisinin up-regulates VE-cadherin expression in human renal glomerular endothelial cells.
    Author: Li L, Chen X, Dong F, Liu Q, Zhang C, Xu D, Allen TD, Liu J.
    Journal: J Cell Mol Med; 2018 Mar; 22(3):2028-2032. PubMed ID: 29193726.
    Abstract:
    The antimalarial agent dihydroartemisinin (DHA) has been shown to be anti-inflammatory. In this study, we found that DHA increased the expression of the junctional protein vascular endothelial (VE)-cadherin in human renal glomerular endothelial cells. In addition, DHA inhibited TGF-β RI-Smad2/3 signalling and its downstream effectors SNAIL and SLUG, which repress VE-cadherin gene transcription. Correspondingly, DHA decreased the binding of SNAIL and SLUG to the VE-cadherin promoter. Together, our results suggest an effect of DHA in regulating glomerular permeability by elevation of VE-cadherin expression.
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