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  • Title: Anti-inflammatory meroterpenoids from the mangrove endophytic fungus Talaromyces amestolkiae YX1.
    Author: Chen S, Ding M, Liu W, Huang X, Liu Z, Lu Y, Liu H, She Z.
    Journal: Phytochemistry; 2018 Feb; 146():8-15. PubMed ID: 29197643.
    Abstract:
    Four previously undescribed meroterpenoids, amestolkolides A-D, along with three known compounds were isolated from the mangrove endophytic fungus Talaromyces amestolkiae YX1 cultured on wheat solid-substrate medium culture. Their structures were elucidated by a combination of spectroscopic analyses. The absolute configurations of amestolkolides B and C, and purpurogenolide E were determined by single-crystal X-ray diffraction using Cu Kα radiation, and those of amestolkolides A and D were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. The absolute configuration of amestolkolides A-D, and purpurogenolide E (9R) at C-9 was different from that of analogues (9S) in references, so that their plausible and distinct biosynthetic pathways were proposed. Amestolkolide B showed strong anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide activated in RAW264.7 cells with IC50 value of 1.6 ± 0.1 μM.
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