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  • Title: Interleukin-23 receptor polymorphism (rs10889677 A/C) in ankylosing spondylitis: Meta-analysis in Caucasian and Asian populations.
    Author: Han R, Xia Q, Xu S, Fan D, Pan F.
    Journal: Clin Chim Acta; 2018 Feb; 477():53-59. PubMed ID: 29198991.
    Abstract:
    BACKGROUND: The association between interleukin-23 receptor (IL23R) gene rs10889677 polymorphism and ankylosing spondylitis (AS) susceptibility was inconsistent in the recent literatures. A systematic review and meta-analysis was therefore performed. METHODS: Online electronic databases were searched for relevant studies published up to November 2017. Meta-analyses were performed for the comparisons of allele (A versus C) and multiple genetic models, including dominant, recessive, heterozygous, and homozygous models using fixed or random effects models. Odds ratios (OR) with 95% confidence intervals (95%CI) were utilized to assess the potential relationship. RESULTS: Sixteen studies containing 19 separate comparisons, totaling 6450 cases and 8009 controls were included. A significant association between rs10889677 A allele and AS susceptibility was detected (OR=1.136, 95%CI=1.043-1.236, P=0.003). Stratified analysis by ethnicity indicated that rs10889677 A allele was significantly associated with AS in Europeans (OR=1.192, 95%CI=1.080-1.315, P<0.001), but not Asians (OR=1.045, 95%CI=0.913-1.197, P=0.523). In addition, there were no significant associations between rs10889677 polymorphism and AS susceptibility in any of dominant, recessive, homozygous and heterozygous models. CONCLUSION: This meta-analysis demonstrates that IL23R gene rs10889677 A allele confers increased risk of AS in Europeans, but its role in Asian populations needs further exploration.
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