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  • Title: A highly printable and biocompatible hydrogel composite for direct printing of soft and perfusable vasculature-like structures.
    Author: Suntornnond R, Tan EYS, An J, Chua CK.
    Journal: Sci Rep; 2017 Dec 04; 7(1):16902. PubMed ID: 29203812.
    Abstract:
    Vascularization is one major obstacle in bioprinting and tissue engineering. In order to create thick tissues or organs that can function like original body parts, the presence of a perfusable vascular system is essential. However, it is challenging to bioprint a hydrogel-based three-dimensional vasculature-like structure in a single step. In this paper, we report a new hydrogel-based composite that offers impressive printability, shape integrity, and biocompatibility for 3D bioprinting of a perfusable complex vasculature-like structure. The hydrogel composite can be used on a non-liquid platform and is printable at human body temperature. Moreover, the hydrogel composite supports both cell proliferation and cell differentiation. Our results represent a potentially new vascularization strategy for 3D bioprinting and tissue engineering.
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