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  • Title: Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections.
    Author: El-Halfawy OM, Naguib MM, Valvano MA.
    Journal: Antimicrob Resist Infect Control; 2017; 6():120. PubMed ID: 29204272.
    Abstract:
    Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically achievable concentrations. Adding low dose of colistin improved the efficacy of the combo, especially at conditions mimicking CF respiratory secretions.
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