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  • Title: Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability.
    Author: Imbrogno J, Rogers L, Thomas DA, Jensen KF.
    Journal: Chem Commun (Camb); 2017 Dec 19; 54(1):70-73. PubMed ID: 29210378.
    Abstract:
    Continuous processing of pharmaceuticals opens opportunities for continuous separation based on wettability of polymer membranes. Dual use of hydrophobic and hydrophilic membranes realize in-line liquid-liquid extraction in the synthesis of four essential APIs. A secondary membrane with opposite wetting characteristics proves critical to phase separation of aqueous-organic reaction streams.
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