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  • Title: Vision in former very low birthweight young adults with and without retinopathy of prematurity compared with term born controls: the NZ 1986 VLBW follow-up study.
    Author: Darlow BA, Elder MJ, Kimber B, Martin J, Horwood LJ.
    Journal: Br J Ophthalmol; 2018 Aug; 102(8):1041-1046. PubMed ID: 29212820.
    Abstract:
    OBJECTIVE: There are few data on visual outcomes in adulthood of former very low birthweight (VLBW; <1500 g) infants. We aimed to assess vision at 27-29 years in a national cohort of VLBW infants born in 1986 and assessed for retinopathy of prematurity (ROP) when no treatment was available, compared with term born controls. METHODS: The cohort and controls attended a 2-day assessment in Christchurch as part of a larger study. Visual assessment included glasses prescription measured by focimeter, logarithm of the minimum angle of resolution (logMAR) distance visual acuity (VA), contrast sensitivity, autorefraction, retinal photographs and a questionnaire on vision-related everyday activities. Rates of reduced VA and myopia in the VLBW cohort at 27-29 were compared with the results of vision testing at 7-8 years. RESULTS: 250 VLBW adults (77% those alive) gave study consent and 229 (45 with a history of ROP) were assessed in Christchurch, plus 100 term born controls. VLBW adults with ROP had reduced VA compared with no ROP and controls (mean logMAR score (SD); 0.003 (0.19), -0.021 (0.16), -0.078 (0.09), P=0.001). There were no differences in myopia (>2 D) between the groups but high myopia (>5 D) was confined to those with ROP. VLBW adults with ROP drove a car less often and had higher difficulties with everyday activities scores due to eyesight. Between 7-8 and 27-29 years rates of reduced VA were stable but myopia increased. CONCLUSION: Former VLBW young adults with ROP have ongoing problems with vision affecting daily living and should continue in regular ophthalmological review. TRIAL REGISTRATION NUMBER: ACTRN12612000995875, Pre-results .
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