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  • Title: Halogenated pyrimidines as radiosensitizers for high-LET radiation.
    Author: Atcher RW, Russo A, DeGraff WG, Moore M, Grdina DJ, Mitchell JB.
    Journal: Radiat Res; 1989 Feb; 117(2):351-5. PubMed ID: 2922478.
    Abstract:
    The incorporation of iododeoxyuridine (IdUrd) into Chinese hamster cells was examined as a possible radiosensitizer for fission spectrum neutrons. Dose-response curves comparing both X rays and neutrons in the same cell line with the same IdUrd replacement showed a similar radiation enhancement for IdUrd incorporation. Enhancement ratios at the 1% survival level were 1.8 for X rays and 1.5 for fission spectrum neutrons. While the mechanism of this enhancement in the response for fission neutron radiation is unclear, these positive data should support further exploration to determine if halogenated pyrimidine incorporation results in sensitization for neutron energies employed in therapy.
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