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  • Title: QSAR studies and antimicrobial potential of 1,3-thiazolylphosphonium salts.
    Author: Trush MM, Kovalishyn VV, Blagodatnyi VM, Brovarets VS, Pilyo SG, Prokopenko VM, Hodyna DM, Metelytsia LO.
    Journal: Ukr Biochem J; 2016; 88(4):57-65. PubMed ID: 29235765.
    Abstract:
    The regression QSAR models were built to predict the antimicrobial activity of new thiazole derivatives. Compounds with high predicting activity were synthesized and evaluated against Gram-positive and Gram-negative bacteria and fungi. 1,3-Thiazole-4-ylphosphonium salts 4 and 5 displayed good antibacterial properties and high antifungal activity. The predictions are in a good agreement with the experiment results, which indicate the good predictive power of the created QSAR models.
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