These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Stimulatory effect of testosterone on renal 25-hydroxyvitamin D-3 1 alpha-hydroxylase in guinea pig.
    Author: Hagenfeldt Y, Eriksson H, Björkhem I.
    Journal: Biochim Biophys Acta; 1989 Mar 14; 1002(1):84-8. PubMed ID: 2923868.
    Abstract:
    Castration of male guinea pigs reduced the activity of the renal mitochondrial 25-hydroxyvitamin D-3 1 alpha-hydroxylase by about 50% without affecting the apparent Km for the reaction. Testosterone substitution for 10 days after castration increased the activity to about the same level as that of sham-operated animals. Ovariectomy of female guinea pigs had no effect on the 1 alpha-hydroxylase activity. Administration of testosterone to ovariectomized female guinea pigs increased the activity by about 50%, again without affecting the apparent Km. The different manipulations had no significant effect on circulating levels of 1,25-dihydroxyvitamin D or vitamin D-binding protein (DBP). It is concluded that testosterone may be a regulator of the 25-hydroxyvitamin D-3 1 alpha-hydroxylase in guinea pigs.
    [Abstract] [Full Text] [Related] [New Search]