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  • Title: Administration of D-aspartate increases D-aspartate oxidase activity in mouse liver.
    Author: Yamada R, Nagasaki H, Nagata Y, Wakabayashi Y, Iwashima A.
    Journal: Biochim Biophys Acta; 1989 Mar 24; 990(3):325-8. PubMed ID: 2923913.
    Abstract:
    Oral administration of D-aspartate to mice for 2 weeks by addition of the amino acid to drinking water produced a nearly 4-fold increase in liver D-aspartate oxidase (EC 1.4.3.1) activity, whereas no increase was induced by L-aspartate administered in the same way. Administration of D-aspartate also produced a small significant increase in the kidney enzyme activity, but L-aspartate administration increased the activity as well. The enzyme activity in the brain and muscle was not affected by administration of either D- or L-aspartate. Intraperitoneal administration of D-aspartate increased the enzyme activity only in the liver, and other compounds tested, including D-glutamate and D-alanine, could not replace D-aspartate. The results indicate a specific relationship between D-aspartate and D-aspartate oxidase and suggest that the amino acid is, in fact, a physiological substrate of the enzyme.
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