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  • Title: Management of Refractory Pediatric Kaposiform Hemangioendothelioma With Sirolimus and Aspirin.
    Author: MacFarland SP, Sullivan LM, States LJ, Bailey LC, Balamuth NJ, Womer RB, Olson TS.
    Journal: J Pediatr Hematol Oncol; 2018 May; 40(4):e239-e242. PubMed ID: 29240034.
    Abstract:
    Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor characterized by aggressive local invasion and a syndrome of platelet trapping known as Kasabach-Merritt phenomenon that, through deposition of platelet derived growth factors, may perpetuate the growth of the tumor. Although many cases of KHE are successfully treated with local control or low-intensity chemotherapy, some cases are often refractory even to aggressive treatment. Herein, we describe a patient with a refractory, recurrent KHE despite multiple attempts at local control and intensive chemotherapy, that ultimately was successfully treated with rationally designed and low-intensity combination therapy of sirolimus and aspirin.
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