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  • Title: Regional calcium accumulation and kainic acid (KA)-induced limbic seizure status in rats.
    Author: Tanaka S, Sako K, Tanaka T, Yonemasu Y.
    Journal: Brain Res; 1989 Jan 30; 478(2):385-90. PubMed ID: 2924137.
    Abstract:
    The sites of calcium accumulation were studied by 45Ca autoradiography during kainic acid (KA)-induced limbic seizure in rats. Two hours after KA injection into unilateral amygdala, calcium accumulated in CA3 of the hippocampus, lateral septal nucleus and thalamic reticular nucleus on KA-injected side. Those sites coincided with the sites where neuronal cell damage appeared 4 h after KA injection. These results suggested that regional calcium accumulation might be responsible for neuronal cell loss induced by seizures.
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