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  • Title: Viscoelastic properties of human aryepiglottic fold and ventricular fold tissues at phonatory frequencies.
    Author: Kimura M, Chan RW.
    Journal: Laryngoscope; 2018 Aug; 128(8):E296-E301. PubMed ID: 29243255.
    Abstract:
    OBJECTIVE: The purpose of this study was to quantify the viscoelastic shear properties of the human ventricular fold (or false vocal fold) mucosa and aryepiglottic fold mucosa at frequencies of phonation. METHODS: Linear viscoelastic shear properties of the mucosa of false vocal fold and aryepiglottic fold specimens from seven cadaveric subjects were determined as functions of frequency (5-250 Hz) and compared to those of the true vocal fold cover. Measurements of elastic shear modulus (G') and dynamic viscosity (η') were made with a controlled-strain simple-shear rheometer. Linear least-squares regression was conducted to curve-fit log G' and log η' versus log frequency, and statistical analysis was performed with one-way analysis of variance. RESULTS: All specimens showed similar frequency dependence of the viscoelastic functions G' and η', with G' gradually increasing with frequency and η' monotonically decreasing with frequency. The magnitudes of G' and η' of the false fold mucosa were generally higher than those of the aryepiglottic fold mucosa and true vocal fold cover, but there were no significant differences in G' and η' among the false fold, aryepiglottic fold, and true vocal fold. CONCLUSION: The false vocal fold and aryepiglottic fold mucosa showed similar frequency dependence and a similar range of tissue viscoelastic behavior as the true vocal fold. These preliminary findings suggested that such tissues could become candidates for the replacement of the true vocal fold lamina propria in patients with significant tissue loss and deficiencies, for those requiring laryngeal reconstruction following partial laryngectomy or airway reconstruction. LEVEL OF EVIDENCE: NA. Laryngoscope, E296-E301, 2018.
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