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  • Title: Synthesis of the major inducible heat shock protein in rat hippocampus after neonatal hypoxia-ischemia.
    Author: Dwyer BE, Nishimura RN, Brown IR.
    Journal: Exp Neurol; 1989 Apr; 104(1):28-31. PubMed ID: 2924867.
    Abstract:
    Rats aged 7 days were exposed to 3.5 h of cerebral hypoxia-ischemia produced by unilateral common carotid artery ligation combined with hypoxia (8% oxygen). The major inducible heat-shock protein, HSP-68, was synthesized in ipsilateral but not contralateral (control) hippocampus during early recovery (1 and 3 h). HSP-68 synthesis was not detected during longer recovery periods. The presence of HSP-68 was confirmed by Western blotting and immunostaining with a polyclonal antibody to HSP-68.
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