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  • Title: Morphological Transformation of Giant-Cell Tumor of Bone After Treatment with Denosumab: A Case Report.
    Author: Zhang Y, Ilaslan H, Krishnaney AA, Bauer TW.
    Journal: JBJS Case Connect; 2016; 6(3):e74. PubMed ID: 29252651.
    Abstract:
    CASE: Denosumab, an inhibitor of RANKL (receptor activator of nuclear factor κ-B ligand), was recently introduced for the treatment of giant-cell tumor of bone (GCTB). We describe the clinical, radiographic, and histological features of a GCTB of the spine in a 24-year-old woman that progressed after neoadjuvant treatment with denosumab. Disappearance of the multinuclear osteoclastic giant cells was accompanied by newly formed woven bone, which was deposited in interconnected strands with a prominent fibrovascular stroma that was histologically and radiographically similar to that of an osteoblastoma. CONCLUSION: Pathologists, radiologists, and surgeons should be aware of this post-treatment transformation to avoid misdiagnosis.
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