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  • Title: Frozen-Thawed Embryo Transfer Cycles Have a Lower Incidence of Ectopic Pregnancy Compared With Fresh Embryo Transfer Cycles.
    Author: Zhang X, Ma C, Wu Z, Tao L, Li R, Liu P, Qiao J.
    Journal: Reprod Sci; 2018 Sep; 25(9):1431-1435. PubMed ID: 29254433.
    Abstract:
    OBJECTIVE: To evaluate the risk of ectopic pregnancy of embryo transfer. DESIGN: A retrospective cohort study on the incidence of ectopic pregnancy in fresh and frozen-thawed embryo transfer cycles from January 1st, 2010, to January 1st, 2015. PATIENTS: Infertile women undergoing frozen-thawed transfer cycles or fresh transfer cycles. INTERVENTION: In-vitro fertilization, fresh embryo transfer, frozen-thawed embryo transfer, ectopic pregnancy. MAIN OUTCOME MEASURES: Ectopic pregnancy rate and clinical pregnancy rate. RESULT: A total of 69 756 in vitro fertilization-embryo transfer cycles from 2010 to 2015 were analyzed, including 45 960 (65.9%) fresh and 23 796 (34.1%) frozen-thawed embryo transfer cycles. The clinical pregnancy rate per embryo transfer was slightly lower in fresh embryo transfer cycles compared with frozen-thawed embryo transfer cycles (40.8% vs 43.1%, P < .001). Frozen-thawed embryo transfer is associated with a lower incidence of ectopic pregnancy per clinical pregnancy, compared with fresh embryo transfers (odds ratio = 0.31; 95% confidence interval = 0.24-0.39). Female age and body mass index have no influence on ectopic pregnancy. In the frozen-thawed embryo transfer cycles, blastocyst transfer shows a significantly lower incidence of ectopic pregnancy (0.8% vs 1.8%, P = .002) in comparison with day 3 cleavage embryo transfer. CONCLUSION: The risk of ectopic pregnancy is lower in frozen-thawed embryo transfer cycles than fresh embryo transfer cycles, and blastocyst transfer could further decrease the ectopic pregnancy rate in frozen-thawed embryo transfer cycles.
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