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  • Title: Myopathy associated with desmin type intermediate filaments. An immunoelectron microscopic study.
    Author: Pellissier JF, Pouget J, Charpin C, Figarella D.
    Journal: J Neurol Sci; 1989 Jan; 89(1):49-61. PubMed ID: 2926442.
    Abstract:
    The muscle biopsy performed in a 58-year-old woman with a myopathy involving pelvic girdle and lower limbs displayed unusual intermediate filament aggregates by light and electron microscopy. No cardiac involvement was detected. The filamentous aggregates selective for type 1 fibers were found in subsarcolemmal and intermyofibrillar areas closely related to Z bands. Immunohistochemical study by light and electron microscopy using polyclonal and monoclonal antibodies and avidin-biotin peroxidase method revealed that aggregates consisted of desmin filaments. Desmin positive material was unstained with vimentine antibodies.
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